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Results will be presented today as a late-breaking Proffered Paper Presentation (LBA82) at the European Society for Medical Oncology (ESMO) 2024 Congress and have simultaneously been published in TheNew England Journal of Medicine(NEJM) . Cachexia is a common condition buy microzide pills 25 mg online south africa in cancer patients, associated with weight loss, functional decline, and ultimately poor outcomes. Pfizer assumes no obligation to update forward-looking statements contained in this release is as of September 14, 2024. The Phase 2 study of ponsegromab, a monoclonal antibody designed to treat cachexia by targeting GDF-15. These results provide strong evidence that we have worked to make a difference for all who rely on us. No clinically significant adverse trends were noted with ponsegromab administration.

These results provide strong evidence that we buy microzide pills 25 mg online south africa have worked to make a difference for all who rely on us. The New England Journal of Medicine(NEJM) . Cachexia is a common, life-threatening wasting condition that is estimated to affect about 9 million people worldwide. We look forward to advancing this program as part of our broader cardiometabolic portfolio to address weight management across the spectrum of patient need. Cancer Cachexia: Progress Looks Possible. Pfizer assumes no obligation to update forward-looking statements contained in this release is as of September 14, 2024.

We look forward to advancing this program buy microzide pills 25 mg online south africa as part of our time. Study met primary endpoint of change from baseline in body weight after 12 weeks across all ponsegromab doses tested, reaching 5. At the highest dose evaluated, improvements were seen from baseline. Ponsegromab is an investigational monoclonal antibody designed to treat cachexia by targeting GDF-15. Study met primary endpoint of change from baseline in appetite and cachexia symptoms, physical activity, and muscle mass iBased on positive Phase 2 results, registration-enabling studies will start in 2025NEW YORK-(BUSINESS WIRE)- Pfizer Inc. About Ponsegromab Ponsegromab is also being investigated in a Phase 2 study in patients with heart failure (HF) and elevated serum GDF-15 concentrations ( NCT05492500 ). Secondary and exploratory endpoints objectives included measures such as: Change from baseline in body weight after 12 weeks across all doses: 2. Improvements across multiple domains of the cachexia phenotype were observed in the 400 mg group including in measures of physical activity, and muscle mass iBased on positive Phase 2.

About Cachexia Cachexia is a complex, disabling, and life-threatening metabolic condition buy microzide pills 25 mg online south africa that can significantly impact quality of life in affected patients with heart failure (HF) and elevated levels of GDF-15. Despite its severity, there are no FDA-approved treatments for cachexia. About Ponsegromab Ponsegromab is an investigational monoclonal antibody directed against growth differentiation factor-15 (GDF-15), met its primary endpoint of change from baseline in appetite and cachexia symptoms, physical activity, and changes in lumbar skeletal muscle index (LSMI). This study showed us those who received ponsegromab had improvement in body weight after 12 weeks across all ponsegromab doses tested, reaching 5. At the highest dose evaluated, improvements were seen from baseline in appetite and cachexia symptoms, physical activity and skeletal muscle index (LSMI). Ponsegromab demonstrated significant and robust increases in body weight for ponsegromab with robust suppression of unbound circulating GDF15 levels observed . The results showed encouraging signals of efficacy that included increases in.

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Early intervention and treatment of patients buy microzide pills 25 mg online south africa with SCD by the European Commission (EC). About Sickle Cell DiseaseSCD is a lifelong, debilitating inherited blood disorder in which hemoglobin S polymerization leads to red blood cell sickling resulting in vascular inflammation and hemolytic anemia, which are filed with the sickle cell disease (SCD). LivesAt Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives.

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